We had an adverse reaction to the MMR vaccine.

Last week, our son Ox had an adverse reaction to the MMR vaccine.  I’m glad, and I’m grateful.

First, the downside. Ox came home from daycare with a fever hovering around 100° F/38° C. That’s high enough to worry first-time parents, and it was persistent. By Friday night he’d been feverish for days and couldn’t sleep. When we measured him at 103°/39°, we finally called the pediatric nurse hotline at the local children’s hospital. The nurse was cool, calm, confident, and knowledgeable, just as you expect a nurse to be. She listened to a first-time dad ramble on about his boy’s fever and then let us know that it sounded like a reaction to the MMR vaccine he’d had the week before.

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For his first birthday, Ox got a checkup, the MMR, and a flu shot.

It’s possible that he simply came down with a normal fever and the timing was a coincidence. A lot of reported adverse reactions to vaccines are coincidences. But his experience closely fits the profile of a known vaccine reaction.  Fevers are one of the most common adverse reactions to vaccines, affecting about ten percent of kids after their MMR shots. Our experience was worse than the typical fever; Ox spiked above the usual ceiling of 103° and it lasted a little longer than the standard two days.

Ox is fine today, but I don’t want to minimize the downside. Fevers can be dangerous, of course, leading to dehydration and other serious complications. And while Ox came through just fine, he suffered. He spent a few hot, cranky days unable to sleep or eat comfortably. That hit us, too. As new and first-time parents we don’t have a lot of perspective on what’s serious and what’s not; when the baby’s feverish for that long, it’s scary and upsetting. It also disrupts our lives; we’re very busy but Ox is our priority, so when he’s sick, it’s hard to keep all the other plates spinning efficiently.

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Sick little boys get Star Wars stories.

But it’s good news, over all. Ox spiked a scary fever and spend a miserable few days waiting for it to break, and I’d have him do it again in a heartbeat. Because that fever is an indication that his immune system is responding to his MMR shot, which means he’s developing a powerful, natural immune response to dangerous diseases that could leave him deaf, sterile, or even dead.

Ox suffered an adverse reaction thanks to his pediatrician and the nurses, and I’m sincerely grateful for it. They gave him a shield against pathogens that evolved specifically to attack and ravage him, and that have seriously hurt unvaccinated kids in our community. And they helped make him into a shield in turn, protecting other children through communal immunity.

To Ox’s nurses and doctors and to all the doctors and nurses giving vaccines every day: thank you. You’re standing between our child and a world of suffering, and we’ll always be grateful—even when it causes a fever.

 

 

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No, We Don’t Actually Know That Modern Humans Killed Off The Hobbits

This article is cross-posted from the Social evolution forum where I occasionally write about issues in human evolution.

A new paper out last week in Nature by Sutikna et al. has generated a great deal of excitement, by reporting a revised date range for the diminutive hominin, H. floresiensis, nicknamed the “hobbit” because of its stature (just 3.5 feet for adults). The previous accepted date range for H. floresiensis (95,000-12,000 YBP) implied that humans and hobbits co-existed on Flores for some considerable period of time, prompting fun analogies to the setting of J.R.R Tolkien’s legendarium, Middle-earth, in which humans, hobbits, dwarves, and other races co-existed and interacted. (I actually love this comparison, because it really resonates with my students and makes teaching human evolution easier.)

The original dates for H. floresiensis were based on the (then reasonable) assumption that the depositional sequence in one part of the cave was representative of other parts of the cave. But caves are very active geological systems, and it often turns out—as in this case—that stratigraphy isn’t uniform. When researchers excavated elsewhere in the Liang Bua cave, they found new stratigraphic details (erosion of older deposits followed by filling in of younger deposits) that prompted them to redate the sequence. These new data gave a range of 100-60,000 YBP for the skeletal remains of H. floresiensis and 190,000-50,000 for floresiensis-associated artifacts. The end of this date range—50,000 YBP—happens to be close to the estimated appearance time of modern H. sapiens on the island, which raises some intriguing questions.  For those of you interested in a detailed analysis of the errors of the original dates, and a discussion of some still-unresolved issues with the paper, I highly recommend John Hawks’ post What the revised Liang Bua chronology leaves unanswered.

The cave at Liang Bua. By Rosino - [1], CC BY-SA 2.0, https://commons.wikimedia.org/w/index.php?curid=4567792

Unfortunately, some in the media have gone beyond discussion of those questions and breathlessly reported that these new dates likely mean that our species wiped out the hobbits. While that hypothesis certainly remains a formal–and fascinating– possibility, it’s only one of several. It’s based simply on the observation that under the current chronology, approximately the same time modern humans got to Flores, we stop seeing hobbit tools in the deposits at Liang Bua.

But I want to point out that we have no direct evidence (as yet) showing any interaction between H. sapiens and H. floresiensis, as the authors noted in the closing sentence of their manuscript:

“Parts of southeast Asia may have been inhabited by Denisovans or other hominins during this period, and modern humans had reached Australia by 50 kyr ago. But whether H. floresiensis survived after this time, or encountered modern humans, Denisovans or other hominin species on Flores or elsewhere, remain open questions that future discoveries may help to answer.”

So as of right now, we actually don’t know that humans killed off (either directly or indirectly) hobbits. But this is probably the interpretation that the interested public has walked away with after this week. Call me conservative, but I’m a bit uncomfortable that our speculation might have given people the impression of greater certainty than we actually have.

There are two other aspects of this new finding that interest me. The first is the implication that these older dates have for the debate over whether H. floresiensis was a pathological modern H. sapiens or a separate species with distinctive morphology, likely caused by insular dwarfism. The older date range for these fossils suggests that H. floresiensis was indeed a separate species. Furthermore, as Kristina Kilgrove discusses, these new dates also undermine cryptozoological interpretations of the Indonesian legend of Ebu Gogo as deriving from sustained interactions between humans and H. floresiensis as recently as 12,000 years ago.

The second aspect of these new dates that I find interesting is that although they mean that the hobbits were older than we initially thought, they still fall within the range of time in which it’s possible to obtain ancient DNA from skeletal remains. I have no idea whether there will be further attempts to extract aDNA from the hobbits (previous attempts were unsuccessful), but I continue to be hopeful that someday we will have hobbit DNA. If H. floresiensis is, as some suspect, a descendant of H. erectus, then their genomes could give us a glimpse of that species’ genetic diversity and help us better understand the evolutionary history of ourselves, Neanderthals, and Denisovans.

 

No, Seriously, Don’t Politicize Anti-Vax Sentiment

It’s Wrong and It’s Dangerous

I read Amanda Marcotte’s recent piece, Vaccination becomes a more partisan issue, with Republicans on the wrong side of it, despairingly. The only thing worse than someone trying to politicize ani-vaccine sentiment is someone doing it with a giant megaphone. With all due respect to the author, her piece has two giant flaws. First, its basic premise is wrong: anti-vax ideology is demonstrably not very well connected to basic left-right ideology or party affiliation. Second, her article is ironically more likely to be harmful than a dozen frothing anti-vax pieces.

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